Balanced salt solution

Balanced salt solution 

An essential component in most intra-ocular procedures is a safe irrigating solution. The irrigant helps in keeping the globe inflated and maintain normal pressure volume relationship during surgery. 

With improvement in the surgical techniques and reduced incision size in new techniques like phaco surgery, etc . The volume of irrigating solution required during cataract surgery has increased many folds. The potential for damage to the corneal endothelium and other tissue is related to the chemical composition, ph and osmolarity of the solution which bathes these tissue. The potential for injuries is much greater when a solution is used inside the eye rather than when it is applied externally. There are a number of commercially available irrigating solution viz, normal saline ringer lactate and balanced salt solution has a stable citrate buffer, a pH of 7.5-to 8.2and contains sodium, potassium , calcium, magnesium and chloride ions which a -re essential for cell metabolism. Also its composition appointment that a aqueous humour 

The Rational 

Balanced salt solution has demonstrated to be better intra -ocular irrigating solution then saline and ringer lactate because 

• It is well tolerated by eyes since its pH (7.2-7.4 )and osmolality  (295-305)are closest to the aqueous humour
•  It provides ions like sodium, potassium, magnesium, calcium and chloride which are essential for maintaining cell function 
• It is associated with lower corneal swelling then saline and ringer lactate solution 

 BAlANCED SALT SOLUTION 

It is sterile physiological balanced salt solution of sodium chloride  (NaCl), potassium chloride (KCL), Calcium Chloride  ( CaCl2.2H2O) magnesium Chloride  ( MgCl2.6H2O) Sodium acetate  (C2H3NaO2.3H2O) and sodium dehydrate  ( C6H5Na3O7.2H2O). Balanced salt solution is isotonic to the tissue of the eyes . It is a lit -free solution containing essential ions for normal cell metabolism. 

            "The potential for damage to the corneal endothelium and other tissue is related to the chemical composition, ph and osmolarity of the solution which bathes these tissue. The potential for injuries is much greater when a solution is used inside the eye rather than when it is applied externally "

ADVERSE EFFECTS 

When the corneal endothelium is abnormal, irrigation or any other trauma may result in bolus keratopathy

Special precautions 

This solution contains no preservative and should not be used for more than one patients. Use only if container and seal are undamaged and solutions is clear. The addition of any medication to balanced salt solution may result in damaged to intra-acular tissue. There have been rare reports of corneal clouding or oedema following ocular surgery in which balanced salt solution was used as an irrigating solution. As in all surgical procedures appropriate measure should be taken to cornea and other ocular tissue. 

Not for injection or i.v.infusion 

Composition 

Sodium chloride I.P.o.49%,

Potassium chloride I.P.0.075%

Calcium chloride I.P.0.048%

Magnesium chloride I.P.0.03%

Sodium acetate I.P.0.039%

Sodium citrate I.P.0.17%

Water for injection q.s

Dosage and administration

The ocular irrigating solution should be used according to standard format for each surgical procedures.  

Presentation 

Transparent glass bottles of 500ml with flip off seal 

(Brand available

 BASOL.                sante vision )

(Bottle of 500ml )