Iron-III Hydroxide Polysucrose Complex

Iron-III  Hydroxide Polysucrose Complex

Anaemia in pregnancy is a major health problem in many developing countries where nutritional deficiencies and parasitic infections contribute to increased maternal and perinatal mortality and morbidity. It accounts for 20% of maternal deaths directly or indirectly from Cardiac failure, Haemorrhage or sepsis .In India this incidence of Anaemia in pregnancy has been quoted for 50% to as high as 90% in various . During pregnancy a minimum of 4-6mg of dietary iron absorption is required daily to maintain the iron balance. This can come from 30-40mg of dietary iron which is just not available in the diet of pregnant women. Maternal iron deficiencies and iron deficiencies Anaemia may adversely affect the iron status of the foetus and infant which may in turn lead to deficits in mental and psychomotor development. According to the recommendation of Ministry of Health and Family Welfare at least 100 mg of elemental iron with 0.5mg folic acid must be supplemented in second half of pregnancy for a period of at least 100 day. Despite the availability of large number of iron preparation programmes to the ineffective. This has been attributed to poor patients compliance dosing. Iron (III)Hydroxide polysucrose complex is in ingenious breakthrough in iron delivery technology designed specifically to overcome the drawbacks of traditional iron preparation. It has been recently launched in India as a flavoured chewable tablet.

MECHANISM OF ACTION

The polynuclear ferries -Hydroxide is partly stored as ferritin  (depotiron) after complex -formation with the protein ligand apoferritin of the mitochondria of the liver. Iron is transported in the blood plasma bound to a b-globulin,transferrin . This protein reacts with two atoms of iron per protien molecule with the formation of a pink coloured complex. The major function of transferrin is to

        Iron (111)hydroxide polysucrose complex is an ingenious breakthrough in iron delivery technology designed specifically to overcome the drawbacks of traditional iron preparation. 

Act as the carrier of iron through the body  (transportation to the sites of haemoglobin and myoglobin synthesis as well as to the cells,producing iron containing enzymes ). In doing so, plays a virtual and central role in iron metabolism. Transferrin also has a second important function, that a participating in the bodies defence mechanism against infection. The HB leavel increase quicker and with more certainty then after peroral therapy with ferrious salts,although the kinetics of the iron incorporation is independent of the way of iron administration. 

INDICATION 

All Cases of iron deficiencies in which rapid and reliable substitution of iron is required, especially severe iron deficiencies e.g after Haemorrhage

ADVANTAGES OF IRON  (111)HYDROXIDE POLYSUCROSE COMPLEX 

COMPLIANCE 

• Delicious tablet
• No staining of teeth and gums
• No release of toxic free radicales 
• Safe with out iron overload

1. Convenience 

• Chewable tablet 
• Once daily dosage 
• Can be administered with food and medicament

1. Efficacy  

• On an average, administration of 100mg Fe (III)results in an increase of the haemoglobin level of 2-3% with 3-4 weeks. Rise of haemoglobin values is faster as compared to conventional salt. Also,there is a faster increase of haemotocrit ,MCV,serum iron and ferritin. 
• Adverse Effects

In rare cases anaphylactoid reaction have been observed  

• Contraindication
• Hypersensitivity. All Cases of iron overload -haemochromatosis and haemosiderosis
• Dosage and administration
• Iron III Hydroxide Polysucrose Complex is available as a flavoured chewable tablet containing 100mg of elemental iron and 1mg folic acid and is meant to be given once daily.  Tablet are delicious due to presence of sucrose which is sweeter then maltose (Hence tastier then iron III Polymaltose complex)